Petroleum hydrocarbon toxicity studies. III. Animal and human response to vapors of Stoddard Solvent

Journal Article · Thu May 01 04:00:00 EDT 1975 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(75)90219-7· OSTI ID:6593533

Carpenter, C P; Kinkead, E R; Geary, Jr, D L; Sullivan, L J; King, J M

The suggested hygienic standard for inhalation of Stoddard Solvent for man is 1.2 mg/liter (200 ppM) based upon the results of inhalation studies with rats and dogs and sensory response of human subjects. Inhalation of 8.2 mg/liter (1400 ppM), substantial saturation at 25/sup 0/C, caused the death of 1 of 15 rats at the termination of 8 hr. Beagle dogs had clonic spasms in 5 hr and cats died between 2.5 and 7.5 hr in roughly equivalent concentrations after signs indicative of central nervous system effect. There were no statistically significant differences between the controls and groups of beagle dogs that inhaled 1.9 mg/liter (330 ppM), 1.1 mg/liter (190 ppM) and 0.48 mg/liter (84 ppM) 6 hr daily, 5 days/wk for 13 wk or 65 exposure days in any of the criteria used for hematology, clinical chemistry, and histopathology. However, rats exposed to 1.9 mg/liter (330 ppM) level for 65 days exhibited slight pathological changes in the kidney, which were related at least in part to the inherent murine nephrosis of the Harlan-Wistar rats employed. The odor threshold as determined in a sniff test by six people is below 0.005 mg/liter (0.9 ppM). In a 15-min inhalation period only slight eye irritation was reported by one of six persons at 0.85 mg/liter (150 ppM). Olfactory fatigue occurred in a short time but 10 min in fresh air restored acuity. 7 references, 13 tables.

• Research Organization: Carnegie-Mellon Univ., Pittsburgh, PA
• OSTI ID: 6593533
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 32:2; ISSN TXAPA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DATA
DOGS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FLUIDS
GASES
INFORMATION
INHALATION
INTAKE
MAMMALS
MAN
NERVOUS SYSTEM
NUMERICAL DATA
OLFACTORY BULBS
ORGANS
PATHOLOGICAL CHANGES
POLLUTION
PRIMATES
RATS
RODENTS
SOLVENTS
TOXICITY
VAPORS
VERTEBRATES