Lung changes in rats inhaling volcanic ash for one year

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6249911

Wehner, A P; Dagle, G E; Clark, M L

Rats were exposed to 5 mg/m/sup 3/ or 50 mg/m/sup 3/ (respirable aerosol concentration) volcanic ash, or to 50 mg/m/sup 3/ quartz, 6 h/day, 5 days/wk, for as long as 12 months. Subgroups of rats were killed at 4-month intervals to determine lesion development as a function of dose and cumulative exposure. Treatment-related lung changes comprised alveolar macrophage accumulation, interstitial reaction, peribronchiolar lymphoid hyperplasia, lymph node hyperplasia, and - in the 50-mg/m/sup 3/ ash-exposed and quartz-exposed rats - alveolar proteinosis. Some of the changes did not increase appreciably after 8 months of exposure, whereas others continued to increase as a function of cumulative exposure. Generally, there were distinct dose-response and agent-response relationships. These trends were also observed in lung weights, respiratory rates, and volumes of mediastinal lymph nodes. Like the histologic changes, the effects on these ancillary parameters also increased in the following order: sham-exposed control group, 5 mg/m/sup 3/ and 50 mg/m/sup 3/ ash-exposed groups, and quartz-exposed positive control group.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 6249911
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 128; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASHES
BIOLOGICAL EFFECTS
BODY
CASCADE MOUNTAINS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
FEDERAL REGION X
INHALATION
INTAKE
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MACROPHAGES
MAMMALS
MOUNTAINS
MT ST HELENS
NORTH AMERICA
ORGANS
PATHOLOGICAL CHANGES
PHAGOCYTES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
USA
VERTEBRATES
WASHINGTON