Lung changes in rats following inhalation exposure to volcanic ash for two years

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80125-6· OSTI ID:5001922

Wehner, A P; Dagle, G E; Clark, M L; Buschbom, R L

Rats were exposed by inhalation to 5 or 50 mg/m/sup 3/ Mount St. Helens volcanic ash, to 50 mg/m/sup 3/ quartz (positive controls), or to filtered room air (sham-exposed controls), for 6 hr/day, 5 days/week, for up to 24 months to investigate biological effects of chronic inhalation exposure to volcanic ash under controlled laboratory conditions. Exposure-related lung changes comprised accelerated respiratory frequency; alveolar macrophage accumulation; interstitial reaction; lymphoreticular reaction in peribronchiolar regions and in mediastinal lymph nodes; alveolar proteinosis in the 50- mg/m/sup 3/ ash- or quartz-exposed groups; increase in fresh lung weights; decreased body weight and increased mortality in the quartz-exposed group; and epidermoid carcinomas especially in the quartz-exposed females and, to a lesser extent, in the 50-mg/m/sup 3/ ash-exposed females. The observed changes reflect significant dose-response and agent-response relationships.

• Research Organization: Pacific Northwest Labs., Richland, WA
• OSTI ID: 5001922
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ASHES
BIOLOGICAL FUNCTIONS
BODY
CARCINOMAS
CASCADE MOUNTAINS
CHALCOGENIDES
CHRONIC EXPOSURE
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FEDERAL REGION X
FUNCTIONS
INFORMATION
INHALATION
INTAKE
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MINERALS
MORTALITY
MOUNTAINS
MT ST HELENS
NEOPLASMS
NORTH AMERICA
NUMERICAL DATA
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
QUARTZ
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SEX DEPENDENCE
SILICON COMPOUNDS
SILICON OXIDES
TOXICITY
USA
VERTEBRATES
WASHINGTON
WEIGHT