Regioselective chemical modification of monoclonal antibodies
Patent
·
OSTI ID:6247802
A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
- Research Organization:
- University of Pittsburgh, PA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-89ER60869
- Assignee:
- University of Pittsburgh (Pittsburgh, PA)
- Patent Number(s):
- 5,208,008
- Application Number:
- 07/613,127
- OSTI ID:
- 6247802
- Country of Publication:
- United States
- Language:
- English
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