Regioselective chemical modification of monoclonal antibodies
Patent
·
OSTI ID:6247802
A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
- Research Organization:
- Univ. of Pittsburgh, PA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-89ER60869
- Assignee:
- University of Pittsburgh (Pittsburgh, PA)
- Patent Number(s):
- 5,208,008
- Application Number:
- 07/613,127
- OSTI ID:
- 6247802
- Resource Relation:
- Patent File Date: 14 Nov 1990
- Country of Publication:
- United States
- Language:
- English
Similar Records
Regioselective chemical modification of monoclonal antibodies
New Insights into the Functional Behavior of Antibodies as Revealed by Binding Studies on an Anti-Uranium Monoclonal Antibody
Solid phase radiosyntheses for antibody labeling; Annual progress report for period July 15, 1989--July 14, 1990
Patent
·
Fri Jan 01 00:00:00 EST 1993
·
OSTI ID:6247802
+1 more
New Insights into the Functional Behavior of Antibodies as Revealed by Binding Studies on an Anti-Uranium Monoclonal Antibody
Conference
·
Wed Mar 17 00:00:00 EST 2004
·
OSTI ID:6247802
+1 more
Solid phase radiosyntheses for antibody labeling; Annual progress report for period July 15, 1989--July 14, 1990
Technical Report
·
Thu Feb 01 00:00:00 EST 1990
·
OSTI ID:6247802