Effects of acute ethanol administration on nocturnal pineal serotonin N-acetyltransferase activity

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90574-7· OSTI ID:6244701

Creighton, J A; Rudeen, P K

The effect of acute ethanol administration on pineal serotonin N-acetyltransferase (NAT) activity, norepinephrine and indoleamine content was examined in male rats. When ethanol was administered in two equal doses (2 g/kg body weight) over a 4 hour period during the light phase, the nocturnal rise in NAT activity was delayed by seven hours. The nocturnal pineal norepinephrine content was not altered by ethanol except for a delay in the reduction of NE with the onset of the following light phase. Although ethanol treatment led to a significant reduction in nocturnal levels of pineal serotonin content, there was no significant effect upon pineal content of 5-hydroxyindoleacetic acid (5-HIAA). The data indicate that ethanol delays the onset of the rise of nocturnal pineal NAT activity.

• Research Organization: Univ. of Missouri, Columbia (USA)
• OSTI ID: 6244701
• Journal Information: Life Sci.; (United States), Vol. 43:24
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ETHANOL
BIOLOGICAL EFFECTS
TRANSFERASES
ENZYME ACTIVITY
ACUTE EXPOSURE
BIOSYNTHESIS
NORADRENALINE
PINEAL GLAND
RATS
SEROTONIN
ADRENAL HORMONES
ALCOHOLS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
ENZYMES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MAMMALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TRYPTAMINES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques