Effects of acute ethanol administration on nocturnal pineal serotonin N-acetyltransferase activity
Journal Article
·
· Life Sci.; (United States)
The effect of acute ethanol administration on pineal serotonin N-acetyltransferase (NAT) activity, norepinephrine and indoleamine content was examined in male rats. When ethanol was administered in two equal doses (2 g/kg body weight) over a 4 hour period during the light phase, the nocturnal rise in NAT activity was delayed by seven hours. The nocturnal pineal norepinephrine content was not altered by ethanol except for a delay in the reduction of NE with the onset of the following light phase. Although ethanol treatment led to a significant reduction in nocturnal levels of pineal serotonin content, there was no significant effect upon pineal content of 5-hydroxyindoleacetic acid (5-HIAA). The data indicate that ethanol delays the onset of the rise of nocturnal pineal NAT activity.
- Research Organization:
- Univ. of Missouri, Columbia (USA)
- OSTI ID:
- 6244701
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 43:24; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACUTE EXPOSURE
ADRENAL HORMONES
ALCOHOLS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
ENZYME ACTIVITY
ENZYMES
ETHANOL
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MAMMALS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PINEAL GLAND
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SEROTONIN
SYMPATHOMIMETICS
SYNTHESIS
TRANSFERASES
TRYPTAMINES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACUTE EXPOSURE
ADRENAL HORMONES
ALCOHOLS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
ENZYME ACTIVITY
ENZYMES
ETHANOL
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MAMMALS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PINEAL GLAND
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SEROTONIN
SYMPATHOMIMETICS
SYNTHESIS
TRANSFERASES
TRYPTAMINES
VERTEBRATES