Uptake and metabolism of indole compounds by the goldfish pineal organ
Journal Article
·
· Gen. Comp. Endocrinol.; (United States)
Indole metabolism was studied in the pineal organ of the goldfish by radioautography and high-performance liquid chromatography. The rate of uptake of tritiated serotonin was rapid in vitro with dense labeling over the photoreceptor cells. Tritiated tryptophan was taken up at a slower rate and the label was distributed evenly over the epithelium. Continual light caused a reduction in the concentration of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) compared to groups exposed to constant darkness both in vivo and in explants, suggesting that these effects are not derived from photoreceptors outside the pineal organ. These data are consistent with the hypothesis that indole metabolism is functionally linked to phototransduction events in the pineal organ of lower vertebrates.
- Research Organization:
- Loyola Univ. Medical Center, Maywood, IL
- OSTI ID:
- 5531375
- Journal Information:
- Gen. Comp. Endocrinol.; (United States), Journal Name: Gen. Comp. Endocrinol.; (United States) Vol. 2; ISSN GCENA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
AZAARENES
AZOLES
BIOLOGICAL LOCALIZATION
BODY
CARBOXYLIC ACIDS
DRUGS
FISHES
GLANDS
GOLDFISH
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
METABOLISM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOTOSENSITIVITY
PINEAL GLAND
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SENSITIVITY
SEROTONIN
SYMPATHOMIMETICS
TRYPTAMINES
TRYPTOPHAN
UPTAKE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
AZAARENES
AZOLES
BIOLOGICAL LOCALIZATION
BODY
CARBOXYLIC ACIDS
DRUGS
FISHES
GLANDS
GOLDFISH
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
METABOLISM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOTOSENSITIVITY
PINEAL GLAND
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SENSITIVITY
SEROTONIN
SYMPATHOMIMETICS
TRYPTAMINES
TRYPTOPHAN
UPTAKE
VERTEBRATES