Selenium-mercury interaction during intestinal absorption of /sup 75/Se compounds in chicks

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · J. Nutr.; (United States)

OSTI ID:6243071

Mykkaenen, H M.M.; Metsaeniitty, L

The effects of inorganic (HgCl/sub 2/) and organic (CH/sub 3/HgCl) mercury on the intestinal absorption of Se compounds (Na/sub 2/(75)SeO/sub 3/, Na/sub 2/(75)SeO4, L-(/sup 75/Se)methionine ((/sup 75/Se)Met)) were determined in 3-wk-old White Leghorn cockerels by the in vivo ligated duodenal loop procedure. The intraduodenal dose contained 0.05 microCi /sup 75/Se, 0.01 mM Se, 150 mM NaCl and 0-1.0 mM Hg. In the presence of 1 mM inorganic Hg in the intraduodenal dose, the absorption of the inorganic /sup 75/Se compounds was only about 65% of that in the control group, whereas only a slight inhibitory effect on (/sup 75/Se)Met absorption was observed. Methylmercury had no effect on (/sup 75/Se)selenite absorption. Precipitation of the /sup 75/Se-selenite in the intestinal lumen partly explained the direct interaction between inorganic Hg and Se compounds. Absorption of (/sup 75/Se)Met and (/sup 75/Se)selenite was also determined in chicks fed after hatching a purified diet supplemented with varying amounts of Hg (0-500 mg/kg) and Se (0-4 mg/kg). Dietary Hg significantly reduced the transfer of (/sup 75/Se)selenite to body by enhancing the accumulation of the isotope in the intestinal tissue. Dietary Hg did not affect the absorption of (/sup 75/Se)Met, but altered the whole-body distribution of this Se compound. Because interaction between Se and Hg was observed mainly between the inorganic compounds and with use of a manyfold excess of Hg over Se, the data suggest that intestinal interaction between these metals is not of great nutritional importance.

• Research Organization: Univ. of Helsinki, Finland
• OSTI ID: 6243071
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 117:8; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIRDS
CARBOXYLIC ACIDS
CHICKENS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOWL
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
LIPOTROPIC FACTORS
MEMBRANE TRANSPORT
MERCURY
MERCURY COMPOUNDS
METALS
METHIONINE
METHYLMERCURY
NUCLEI
NUTRIENTS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES