Evaluation of fast neutron beam teletherapy of metastatic cervical adenopathy from squamous cell carinomas of the heat and neck region. [Comparison of efficacy and complications of fast and neutron and mixed (. gamma. + neutron) beam therapy]

Journal Article · Fri Dec 01 04:00:00 EST 1978 · Cancer; (United States)

OSTI ID:6242056

Griffin, T W ^[1]; Laramore, G E; Parker, R G; Gerdes, A J; Hebard, D W; Blasko, J C; Groudine, M

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1. Univ. of Washingon Hospital, Seattle

One hundred thirteen patients with metastatic cervical adenopathy (MC) from advanced squamous cell carcinoma of the head and neck completed fast neutron beam irradiation between September 1973 and March 1977. With a maximum follow-up time of 49.9 months (mean 14.5 months), 54% of the total group remain disease-free at the sites of their cervical adenopathy. Control of adenopathy measuring 3 cm or less in maximum dimension was 75% with neutrons only and 87.5% with mixed beams. Nodes measuring 3 to 6 cm were controlled 38.1% of the time with neutrons only and 59% of the time with mixed beams. Clinical control of adenopathy measuring greater than 6 cm were controlled. Patients with controlled primary tumors treated with mixed beams had 100% control of nodes measuring 3 cm or less, 96% control of nodes measuring 3 to 6 cm, and 50% control of nodes measuring greater than 6 cm. Overall, the control rate for mixed beams was significantly better than for treatment with neutrons only. Morbidity was less (both acute and late) in the mixed beam-irradiated group.

• OSTI ID: 6242056
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 42:6; ISSN CANCA
• Country of Publication: United States
• Language: English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CARTILAGE
CENTRAL NERVOUS SYSTEM
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
GLANDS
HADRONS
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
METASTASES
MINUTES LIVING RADIOISOTOPES
MUCOUS MEMBRANES
NECK
NECROSIS
NEOPLASMS
NERVOUS SYSTEM
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PHARYNX
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SALIVARY GLANDS
SIDE EFFECTS
SKELETON
SKIN
SPINAL CORD
THERAPY
TISSUES
YEARS LIVING RADIOISOTOPES