Fast neutron teletherapy for advanced carcinomas of the oropharynx

Journal Article · Mon Oct 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90565-0· OSTI ID:5500555

Laramore, G E ^[1]; Blasko, J C; Griffin, T W; Groudine, M T; Parker, R G

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1. Univ. of Washington Hospital, Seattle

A study was performed to assess the efficacy of using fast neutron irradiation to treat advanced squamous cell carcinomas of the oropharynx. Twenty-seven patients were treated with neutrons alone and 21 patients received a combination of fast neutrons and megavoltage photons as part of a mixed beam fractionation scheme. All patients in the study were judged to have less than a 10% chance for 5-year survival with conventional therapy. In the neutron-only group, the initial complete remission rate was 44% (12/27) and the duration of local control ranged between 2 to 41 months (mean = 12.4 months). At the time of writing, 2 patients in this group were still alive and free of disease while 5 patients had died without evidence of tumor at the primary site. The other 15 patients achieved only a partial remission and after completing therapy, their survival ranged between 1 and 15.5 months (mean = 3.2 months). In the mixed beam group, the initial complete remission rate was 67% (14/21) and the duration of local control ranged between 4 and 44 months (mean = 18 months). At the time of writing, 5 patients in this group were still alive and free of disease at the primary site. An additional 3 patients were salvaged successfully with surgery after either an initial control failure or a recurrence. Three other patients died free of disease at the primary site. The survival of the 6 patients in whom there was no initial local control or surgical salvage ranged between 0.5 and 8.5 months (mean = 4.0 months) after completing therapy. Actuarially calculated curves for the duration of local control are shown for the 2 groups of patients and at all follow-up times, the mixed beam group shows a higher degree of local control at the primary site than the neutron-only group.

• OSTI ID: 5500555
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:10; ISSN IOBPD
• Country of Publication: United States
• Language: English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
INFORMATION
ISOLATED VALUES
MEDICINE
MYELITIS
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUTRON THERAPY
NUCLEAR MEDICINE
NUMERICAL DATA
OPTIMIZATION
ORGANS
PATIENTS
PHARYNX
PHOTON BEAMS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RBE
RESPIRATORY SYSTEM
SIDE EFFECTS
SPINAL CORD
THERAPY
TIME DEPENDENCE