Biophysical bases of human plasma lipoprotein polydispersity: role of surface modification

Technical Report · Thu Nov 01 04:00:00 EST 1984

OSTI ID:6240109

Shahrokh, Z

Metabolic depletion of the core of the triglyceride-rich lipoproteins via lipolysis results in the production of polydisperse species of particles within the density range of low density lipoproteins (LDL). Modifications of surface properties of plasma LDL may further contribute to LDL polydispersity. In this dissertation, we study the interactions with LDL of models of lipolysis-related surface products (i.e., phosphatidylcholine vesicles (PCV) and discoidal complexes (DC) of apoprotein AI and phosphatidylcholine) and examine the influence on such interactions of high density lipoproteins (HDL) and other relevant plasma components (lecithin:cholesterol acyltransferase (LCAT), lipid transfer proteins (LTPs), albumin, lysolecithin (LPC)). Based on the studies obtained in this dissertation LDL surface modification may contribute to LDL polydispersity. Since HDL is a major acceptor of PL, formation of surface-modified LDL (e.g., PL-enriched, larged LDL) in vivo would depend on LDL/HDL weight ratio in plasma. 140 references, 50 figures, 15 tables.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6240109
• Report Number(s): LBL-18691; ON: DE85005155
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CHEMISTRY
DATA
DISPERSIONS
EXPERIMENTAL DATA
INFORMATION
LIPIDS
LIPOPROTEINS
MAMMALS
MAN
MATERIALS
METABOLISM
MOLECULAR STRUCTURE
NUMERICAL DATA
ORGANIC COMPOUNDS
PARTICLE SIZE
PRIMATES
PROTEINS
SIZE
SURFACE PROPERTIES
VERTEBRATES