Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report September 1981-August 1982
This report describes the assays of various compounds for their toxicity and anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The chemicals covered in this report are: WR 347, WR 1065, WR 2529, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327 and WR 168643. The drugs and their respective dose modification factors (DMF) for fission neutron gastrointestinal lethality (LD50-6) following intraperitoneal administration are, in decreasing order of effectiveness: WR 44923 (1.77), WR 2529 (1.47), WR 1065 (1.42), WR 2721 (1.39), WR 16843 (1.23). Following per os (P. O.) administration of the drug, the DMF's for the LD50-6 are: WR 109342 (1.47), WR 3689 (1.36), and WR 168643 (1.31). For hematopoietic neutron radiation lethality (LD50-30) the DMF's are: following i.p. administration, WR 2529 (1.04); WR 151327 (1.34), WR 168643 (1.25), WR 44923 (1.22), WR 2721 (1.20), WR 1065 (1.04); following P. O. administration, WR 168643 (1.38), WR 109342 (1.21), WR 3689 (1.04). Using an intestinal microcolony assay system the following drugs provided the listed DMF's against neutron radiation after i.p. injection: WR 3689 (1.24), WR 2721 (1.15), WR 44923 (1.14), and WR 347 (1.05). The protective effects against neutron radiation using an endogenous spleen colony assay and i.p. administration were: WR 3689 (1.18), WR 2529 (1.15), WR 2721 (1.10), WR 44923 (1.02) and WR 347 (0.94).
- Research Organization:
- Louisville Univ., KY (USA). School of Medicine
- OSTI ID:
- 6239804
- Report Number(s):
- AD-A-145500/5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Assessment of antiradiation-drug effectiveness to fission-neutron irradiation. Annual report, 1 September 1982-30 September 1983
In vivo screening of radioprotectors. Annual summary report, March 1982-March 1983
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BARYONS
BODY
CARBOXYLIC ACIDS
CYSTEINE
DIGESTIVE SYSTEM
DRUGS
ELEMENTARY PARTICLES
FERMIONS
FISSION NEUTRONS
GASTROINTESTINAL TRACT
HADRONS
INTESTINES
NEUTRONS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
SPLEEN
THIOLS
TOXICITY