Assessment of antiradiation-drug effectiveness to fission-neutron irradiation. Annual report, 1 September 1982-30 September 1983
This report details scientific results of contracted research testing the ability of newly synthesized anti-radiation drugs to protect critical normal tissues from the adverse effects of fission-neutron irradiation. Fission neutrons were obtained at the Health Physics Research Reactor (HPRR) at Oak Ridge National Laboratory, Oak Ridge, TN. The neutron beam had an average energy of 0.9 MeV and a dose-rate of about 55 Rads per minute. C57B1/6J male mice were used throughout this study. They were irradiated at two meters from the unshielded reactor core with whole-body doses which varied from 0 to 600 rads. The organ systems studied were the hematopoietic and gastrointestinal stem-cell populations. The protectors examined in this study were phosphorothioates which have the greatest chance of improving survival after exposure to radiations which would be experienced in atomic weapon detonation. The drugs covered in this report are: WR-347, WR-1065, WR-2529, WR-2721, WR-3689, WR-44923, WR-109342, WR-151327 and WR-168643. They were injected intraperitoneally at a dose equivalent to the one-third the toxic LD50, 30 minutes prior to irradiation. The results indicate that these agents vary considerably in their ability to protect normal tissues from the adverse effects of neutron irradiation. The study did, however, identify several agents which were surprising in their ability to protect against this high LET radiation.
- Research Organization:
- Louisville Univ., KY (USA). School of Medicine
- OSTI ID:
- 5012109
- Report Number(s):
- AD-A-156947/4/XAB
- Country of Publication:
- United States
- Language:
- English
Similar Records
Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report No. 1, April-August 1981
In vivo screening of radioprotectors. Annual summary report, March 1982-March 1983
Related Subjects
MICE
BIOLOGICAL RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
TESTING
BLOOD CELLS
FISSION NEUTRONS
NUCLEAR EXPLOSIONS
NUCLEAR WEAPONS
REACTOR CORES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
DRUGS
ELEMENTARY PARTICLES
EXPLOSIONS
FERMIONS
HADRONS
MAMMALS
MATERIALS
NEUTRONS
NUCLEONS
RADIATION EFFECTS
REACTOR COMPONENTS
RODENTS
VERTEBRATES
WEAPONS
560152* - Radiation Effects on Animals- Animals