Assessment of antiradiation-drug effectiveness to fission-neutron irradiation. Annual report, 1 September 1982-30 September 1983

Technical Report · Thu Sep 01 04:00:00 EDT 1983

OSTI ID:5012109

Sigdestad, C P

This report details scientific results of contracted research testing the ability of newly synthesized anti-radiation drugs to protect critical normal tissues from the adverse effects of fission-neutron irradiation. Fission neutrons were obtained at the Health Physics Research Reactor (HPRR) at Oak Ridge National Laboratory, Oak Ridge, TN. The neutron beam had an average energy of 0.9 MeV and a dose-rate of about 55 Rads per minute. C57B1/6J male mice were used throughout this study. They were irradiated at two meters from the unshielded reactor core with whole-body doses which varied from 0 to 600 rads. The organ systems studied were the hematopoietic and gastrointestinal stem-cell populations. The protectors examined in this study were phosphorothioates which have the greatest chance of improving survival after exposure to radiations which would be experienced in atomic weapon detonation. The drugs covered in this report are: WR-347, WR-1065, WR-2529, WR-2721, WR-3689, WR-44923, WR-109342, WR-151327 and WR-168643. They were injected intraperitoneally at a dose equivalent to the one-third the toxic LD50, 30 minutes prior to irradiation. The results indicate that these agents vary considerably in their ability to protect normal tissues from the adverse effects of neutron irradiation. The study did, however, identify several agents which were surprising in their ability to protect against this high LET radiation.

• Research Organization: Louisville Univ., KY (USA). School of Medicine
• OSTI ID: 5012109
• Report Number(s): AD-A-156947/4/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
DRUGS
ELEMENTARY PARTICLES
EXPLOSIONS
FERMIONS
FISSION NEUTRONS
HADRONS
MAMMALS
MATERIALS
MICE
NEUTRONS
NUCLEAR EXPLOSIONS
NUCLEAR WEAPONS
NUCLEONS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
REACTOR COMPONENTS
REACTOR CORES
RODENTS
TESTING
VERTEBRATES
WEAPONS