Nuclear medicine progress report for quarter ending September 30, 1985
A new dimethyl-branched fatty acid analogue has been developed with radioiodide stabilized as an iodovinyl moiety at the terminus of the fatty acid chain. The new radioiodinated terminal iodovinyl-3,3-dimethyl-branched fatty acid showed higher myocardial uptake (4.56% dose/gm at 2 min), longer myocardial retention (4.10% dose/gm at 60 min), lower blood levels (0.71% dose/gm at 60 min), and higher heart:blood ratios (5.8:1 at 60 min) in fasted Fischer rats than observed with the corresponding monomethyl analogue. The subcellular distribution and lipid analysis studies of a series of iodovinyl fatty acids which include the straight chain parent, 19-iodo-18-nonadecenoic acid (IVN), monomethyl-branched analogue, 19-iodo-3-(R,S)-methyl-18-nonadecenoic acid (BMIVN), and the dimethyl-branched analogue, 19-iodo-3,3-dimethyl-18-nonadecenoic acid (DMIVN), are described. 4 refs., 3 figs., 3 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6234664
- Report Number(s):
- ORNL/TM-9784; ON: DE86006751
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HEART
HETEROCYCLIC COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LABELLING
LIVER
LUNGS
MAMMALS
MEDICINE
MONOCARBOXYLIC ACIDS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RESPIRATORY SYSTEM
RODENTS
SUBCELLULAR DISTRIBUTION
SYNTHESIS
THYROID
TISSUE DISTRIBUTION
VERTEBRATES