Nuclear medicine progress report for quarter ending September 30, 1985
A new dimethyl-branched fatty acid analogue has been developed with radioiodide stabilized as an iodovinyl moiety at the terminus of the fatty acid chain. The new radioiodinated terminal iodovinyl-3,3-dimethyl-branched fatty acid showed higher myocardial uptake (4.56% dose/gm at 2 min), longer myocardial retention (4.10% dose/gm at 60 min), lower blood levels (0.71% dose/gm at 60 min), and higher heart:blood ratios (5.8:1 at 60 min) in fasted Fischer rats than observed with the corresponding monomethyl analogue. The subcellular distribution and lipid analysis studies of a series of iodovinyl fatty acids which include the straight chain parent, 19-iodo-18-nonadecenoic acid (IVN), monomethyl-branched analogue, 19-iodo-3-(R,S)-methyl-18-nonadecenoic acid (BMIVN), and the dimethyl-branched analogue, 19-iodo-3,3-dimethyl-18-nonadecenoic acid (DMIVN), are described. 4 refs., 3 figs., 3 tabs.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6234664
- Report Number(s):
- ORNL/TM-9784; ON: DE86006751
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine progress report for quarter ending March 31, 1985
Design, synthesis, and evaluation of omega-iodovinyl- and omega-iodoalkyl-substituted methyl-branched long-chain fatty acids
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
IODINE 125
RADIOCHEMISTRY
MONOCARBOXYLIC ACIDS
LABELLING
PYRIDINES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
SUBCELLULAR DISTRIBUTION
TISSUE DISTRIBUTION
EXPERIMENTAL DATA
HEART
KIDNEYS
LIVER
LUNGS
NUCLEAR MEDICINE
RATS
THYROID
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMISTRY
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials