Primary mechanisms of photosensitization by furocoumarins
Conference
·
OSTI ID:6232675
A proper understanding of the PUVA therapy action mechanism requires the synthesis of concepts developed at the level of molecules, single cells and whole organisms. Although progress has been made in identifying key factors within each level of organization, the interrelationships remain obscure. Important unanswered questions at the molecular and cellular levels include: (1) Which excited states of the furocoumarin in molecule (triplet or excited singlet) are involved in the formation of DNA monoadducts, and the conversion of monoadducts to cross-links. (2) How does the spectrum of the incident radiation affect the distribution of the initial photochemical products from the PUVA sensitizers. (3) What are the relative contributions of furocoumarin-DMA monoadducts, furocoumarin-DNA cross-links and singlet oxygen to mutagenesis and lethality in cells, at the furocoumarin and UV-A dose levels corresponging to PUVA therapy. Additional information about these key aspects of furocoumarin photosensitization should lead to a more definitive relationship of the cellular level events to the endpoints observed with PUVA therapy, and suggest directions for potential improvements in the current clinical procedures.
- Research Organization:
- Illinois Inst. of Tech., Chicago (USA). Dept. of Physics
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AS02-76EV02217
- OSTI ID:
- 6232675
- Report Number(s):
- DOE/EV/02217-39; CONF-810716-1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mechanisms of photosensititization by furocoumarins
Investigation of molecular mechanisms in photodynamic action and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, October 1, 1980-September 30, 1981
Mutagenicity of cross-links and monoadducts of furocoumarins (psoralen and angelicin) induced by 360-nm radiation in excision-repair-defective and radiation-insensitive strains of Saccharomyces cerevisiae
Conference
·
Thu Dec 31 23:00:00 EST 1981
·
OSTI ID:6214921
Investigation of molecular mechanisms in photodynamic action and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, October 1, 1980-September 30, 1981
Technical Report
·
Mon Jun 01 00:00:00 EDT 1981
·
OSTI ID:6769186
Mutagenicity of cross-links and monoadducts of furocoumarins (psoralen and angelicin) induced by 360-nm radiation in excision-repair-defective and radiation-insensitive strains of Saccharomyces cerevisiae
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Environ. Mutagen.; (United States)
·
OSTI ID:5941652
Related Subjects
550200* -- Biochemistry
560115 -- Radiation Effects on Biochemicals-- In Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
CHEMICAL REACTIONS
CHEMISTRY
CROSS-LINKING
DNA
ELECTROMAGNETIC RADIATION
MOLECULAR BIOLOGY
MUTAGENESIS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOTOCHEMISTRY
PHOTOSENSITIVITY
POLYMERIZATION
RADIATIONS
SENSITIVITY
SKIN
THERAPY
ULTRAVIOLET RADIATION
560115 -- Radiation Effects on Biochemicals-- In Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
CHEMICAL REACTIONS
CHEMISTRY
CROSS-LINKING
DNA
ELECTROMAGNETIC RADIATION
MOLECULAR BIOLOGY
MUTAGENESIS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOTOCHEMISTRY
PHOTOSENSITIVITY
POLYMERIZATION
RADIATIONS
SENSITIVITY
SKIN
THERAPY
ULTRAVIOLET RADIATION