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Mutagenicity of cross-links and monoadducts of furocoumarins (psoralen and angelicin) induced by 360-nm radiation in excision-repair-defective and radiation-insensitive strains of Saccharomyces cerevisiae

Journal Article · · Environ. Mutagen.; (United States)
; ;
The furocoumarin psoralen can form both monoadducts and cross-links with DNA when combined with 360-nm radiation, whereas the analog angelicin can form monoadducts only. Psoralen plus 360-nm radiation causes mutation induction with a slope of 2 (log-log plot) for a radiation-insensitive strain, whereas angelicin action with 360-nm radiation displays a slope of unity. For a radiation-sensitive mutant defective in the excision-repair pathway, the actions of both angelicin and psoralen plus 360-nm radiation exhibit one-target kinetics, but at higher exposures psoralen plus 360-nm radiation assumes a slope of 2. The simplest explanation for the data is that both cross-links and monoadducts, formed by furocoumarins with DNA when exposed to 360-nm radiation, are capable of inducing mutations, and that monoadducts are repaired 20 times more efficiently than cross-links by the excision-repair pathway.
OSTI ID:
5941652
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 1:1; ISSN ENMUD
Country of Publication:
United States
Language:
English

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Related Subjects

560110 -- Radiation Effects on Biochemicals-- (-1987)
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ANTICOAGULANTS
BENZOFURANS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COUMARIN
COUMARINS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
FUNGI
FURANS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
KINETICS
LACTONES
MICROORGANISMS
MUTAGENESIS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PLANTS
POLYMERIZATION
PSORALEN
PYRANS
RADIATIONS
RADIOINDUCTION
REACTION KINETICS
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
ULTRAVIOLET RADIATION
YEASTS