Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of testicular irradiation on established BPH in the dog: evidence of a non-steroidal testicular factor for BPH maintenance

Journal Article · · J. Urol.; (United States)
OSTI ID:6230859
; ;
Irradiation of the testes of four to 13-year-old male beagles with benign prostatic hyperplasia (BPH) was undertaken to attempt to evaluate the possibility that the testes secrete a non-androgenic accessory sex gland-stimulating substance that may have a critical role in the development of BPH. Thirteen non-irradiated and shoulder irradiated control and 16 beagles subjected to 1500 to 2200 rads single dose testis irradiation had pre-irradiation, interval post-irradiation and terminal caliper measurements of prostatic length, width and depth, prostatic and testicular biopsies, and determination of serum testosterone and estradiol levels. Four beagles survived in a group observed for 109 weeks post testis irradiation, 12 in a group observed for 51 and 10 in a group observed for 59 weeks. The wet weight of the prostate was determined at sacrifice. Ratios of the final/initial length and width and final actual/initial calculated weight of the prostate were significantly decreased in testis-irradiated as compared to control beagles. Histologic evaluation also demonstrated a significant difference in degree of prostatic stimulation in control and testis-irradiated groups. The serum testosterone and estradiol levels were not significantly different in the testis-irradiated and control beagles.
Research Organization:
Northwestern Univ. Medical School, Chicago, IL
OSTI ID:
6230859
Journal Information:
J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 6; ISSN JOURA
Country of Publication:
United States
Language:
English

Similar Records

Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins
Journal Article · Mon Nov 14 23:00:00 EST 2016 · Toxicology and Applied Pharmacology · OSTI ID:22690849
Lonidamine affects testicular steroid hormones in immature mice
Journal Article · Tue May 15 00:00:00 EDT 2007 · Toxicology and Applied Pharmacology · OSTI ID:20976938
Effects of x-irradiation on steroid biotransformations by testicular tissue. Final report, May 1, 1966--July 31, 1976. [Rats]
Technical Report · Sun Aug 01 00:00:00 EDT 1976 · OSTI ID:7144984

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BODY
DOGS
ESTRADIOL
ESTRANES
ESTROGENS
GLANDS
GONADS
HORMONES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROSTATE
RADIATION EFFECTS
RADIATIONS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
VERTEBRATES
WEIGHT