Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow

Conference · Tue Jan 01 00:00:00 EST 1985

OSTI ID:6230394

Eckerman, K F

Epidemiological surveys on man and results from animal experiments have shown that two tissues associated with the skeleton are of primary concern with respect to cancer induction by ionizing radiation. These are the cells on or near endosteal surfaces of bone, from which osteosarcomas are thought to arise, and hematopoietic bone marrow, which is associated with leukemia. The complex geometry of the soft tissue-bone intermixture makes calculations of absorbed dose to these target regions a difficult problem. In the case of photon or neutron radiations, charged particle equilibrium may not exist in the vicinity of soft tissue-bone mineral interface. In this paper a general study of the dosimetry of radionuclides within the skeleton is presented. Dosimetric data consistent with the MIRD schema and reflecting the physical and anatomical parameters defining the energy deposition are tabulated for the relevant target regions. 27 refs., 5 figs., 5 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6230394
• Report Number(s): CONF-851113-5; ON: DE86006096
• Resource Relation: Conference: Radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 5 Nov 1985
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
RADIATION DOSES
ELECTRON BEAMS
DOSIMETRY
MATHEMATICAL MODELS
DESIGN
TRABECULAR BONE
MAN
MONTE CARLO METHOD
VERTEBRAE
ANIMAL TISSUES
ANIMALS
BEAMS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DOSES
HEMATOPOIETIC SYSTEM
LEPTON BEAMS
MAMMALS
ORGANS
PARTICLE BEAMS
PRIMATES
SKELETON
TISSUES
VERTEBRATES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
560151 - Radiation Effects on Animals- Man