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Title: Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow

Abstract

Epidemiological surveys on man and results from animal experiments have shown that two tissues associated with the skeleton are of primary concern with respect to cancer induction by ionizing radiation. These are the cells on or near endosteal surfaces of bone, from which osteosarcomas are thought to arise, and hematopoietic bone marrow, which is associated with leukemia. The complex geometry of the soft tissue-bone intermixture makes calculations of absorbed dose to these target regions a difficult problem. In the case of photon or neutron radiations, charged particle equilibrium may not exist in the vicinity of soft tissue-bone mineral interface. In this paper a general study of the dosimetry of radionuclides within the skeleton is presented. Dosimetric data consistent with the MIRD schema and reflecting the physical and anatomical parameters defining the energy deposition are tabulated for the relevant target regions. 27 refs., 5 figs., 5 tabs.

Authors:
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
OSTI Identifier:
6230394
Report Number(s):
CONF-851113-5
ON: DE86006096
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Conference
Resource Relation:
Conference: Radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 5 Nov 1985
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; RADIATION DOSES; ELECTRON BEAMS; DOSIMETRY; MATHEMATICAL MODELS; DESIGN; TRABECULAR BONE; MAN; MONTE CARLO METHOD; VERTEBRAE; ANIMAL TISSUES; ANIMALS; BEAMS; BODY; BONE TISSUES; CONNECTIVE TISSUE; DOSES; HEMATOPOIETIC SYSTEM; LEPTON BEAMS; MAMMALS; ORGANS; PARTICLE BEAMS; PRIMATES; SKELETON; TISSUES; VERTEBRATES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 560151 - Radiation Effects on Animals- Man

Citation Formats

Eckerman, K F. Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow. United States: N. p., 1985. Web.
Eckerman, K F. Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow. United States.
Eckerman, K F. 1985. "Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow". United States. https://www.osti.gov/servlets/purl/6230394.
@article{osti_6230394,
title = {Aspects of the dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow},
author = {Eckerman, K F},
abstractNote = {Epidemiological surveys on man and results from animal experiments have shown that two tissues associated with the skeleton are of primary concern with respect to cancer induction by ionizing radiation. These are the cells on or near endosteal surfaces of bone, from which osteosarcomas are thought to arise, and hematopoietic bone marrow, which is associated with leukemia. The complex geometry of the soft tissue-bone intermixture makes calculations of absorbed dose to these target regions a difficult problem. In the case of photon or neutron radiations, charged particle equilibrium may not exist in the vicinity of soft tissue-bone mineral interface. In this paper a general study of the dosimetry of radionuclides within the skeleton is presented. Dosimetric data consistent with the MIRD schema and reflecting the physical and anatomical parameters defining the energy deposition are tabulated for the relevant target regions. 27 refs., 5 figs., 5 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/6230394}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}

Conference:
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