Radionuclide skeletal survey in neuroblastoma. [/sup 99m/Tc--methylene diphosphonate and pyrophosphate]

Conference · Tue May 01 04:00:00 EDT 1979 · Radiology; (United States)

OSTI ID:6228334

Howman-Giles, R B; Gilday, D L; Ash, J M

Of 63 /sup 99m/Tc-phosphate bone images in 49 patients with neuroblastoma, 41 were abnormal, 17 showed tracer uptake within the primary tumor, 29 showed evidence of skeletal metastatic disease, and 17 demonstrated renal/urinary tract involvement. The metastases were asymmetric in 24 patients and symmetrical in 9, in whom they involved the metaphyses and epiphyses of the long bones. Except for one patient with multiple cold areas, all metastases were seen as focal hyperactive regions. Eleven of 42 skeletal radiographic surveys were abnormal. The radionuclide study appears to be more accurate than skeletal radiography in estimating bone involvement in neuroblastoma. Primary tumor concentration of the tracer is almost pathognomonic of neural crest neoplasms in childhood.

• Research Organization: Hospital for Sick Children, Toronto, Ontario
• OSTI ID: 6228334
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 131:2
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
550901 -- Pathology-- Tracer Techniques
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOMEDICAL RADIOGRAPHY
BODY
CHILDREN
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ESTERS
HOURS LIVING RADIOISOTOPES
INFANTS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MAN
MEDICINE
METASTASES
NEONATES
NEOPLASMS
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PHOSPHONIC ACID ESTERS
PHOSPHORUS COMPOUNDS
PRIMATES
PYROPHOSPHATES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
URINARY TRACT
VERTEBRATES
YEARS LIVING RADIOISOTOPES