Radionuclide bone scanning in neuroblastoma: skeletal metastases and primary tumor localization of /sup 99m/Tc-MDP

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.141.3.469· OSTI ID:5546715

Podrasky, A E; Stark, D D; Hattner, R S; Gooding, C A; Moss, A A

Of 42 radionuclide bone scans in 35 children with neuroblastoma, 21 were abnormal for the presence of skeletal metastases. Of the 21 abnormal scans, 16 were corroborated by positive bone-marrow biopsy or clinical data. The false-negative and false-positive rates for bone scanning were 4.8% and 9.5%, respectively. Calcification of the primary tumor was seen on pretreatment computed tomographic (CT) scans in 24 (89%) of 27 cases, while only 13 (48%) of 27 were detectable by plain radiographs. Uptake of /sup 99m/Tc methylene diphosphate /sup 99m/Tc-MDP) by the primary tumor occurred in 20 of 27 cases, but correlation between tumor uptake and calcification was not statistically significant. All children with markedly elevated urinary vanillylmandelic acid exhibited primary tumor uptake. Survival was not affected independently by primary tumor uptake.

• Research Organization: Department of Radiology, University of California Medical Center, San Francisco
• OSTI ID: 5546715
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 141:3; ISSN AAJRD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
AGE GROUPS
AMINES
ANIMAL TISSUES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BIOMEDICAL RADIOGRAPHY
BODY
BODY FLUIDS
BONE MARROW
BONE TISSUES
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHILDREN
COMPUTERIZED TOMOGRAPHY
CONNECTIVE TISSUE
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOPAMINE
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MEDICINE
METABOLITES
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PHENOLS
PHOSPHATES
PHOSPHORUS COMPOUNDS
POLYPHENOLS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
SKELETON
STEROID HORMONES
SYMPATHOMIMETICS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TECHNETIUM PHOSPHATES
TISSUES
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
URINE
USES
WASTES
X RADIATION
YEARS LIVING RADIOISOTOPES