Long-term exposure to low levels of air pollutants: effects on pulmonary function in the beagle

Journal Article · Wed Jan 01 04:00:00 EST 1969 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1969.10666803· OSTI ID:6227213

Vaughan, Jr, T R; Jennelle, L F; Lewis, T R

104 beagles were exposed to air containing either natural or photochemically-reacted auto exhaust, NO/sub x/ SO/sub x/, or combinations for 16 hr/day, 7 days/week, for 18 months. Exhaust air was 100 ppM CO, 24 to 30 ppM hydrocarbon; NO/sub x/ varied with treatment. NO/sub x/ was 0.5 to 1.0 ppM NO/sub 2/ plus 0.2 ppM NO or 1.0 to 2.0 ppM NO plus 0.2 ppM NO/sub 2/. No differences were observed in pulmonary function as measured by single breath CO diffusing capacity, dynamic pulmonary compliance, or total expiratory pulmonary resistance. Measurements were done in room air after 18 months of exposure, and this could have obscured effects. Also, these methods may not be sensitive enough because standard deviation was normally large; in addition, techniques show normal values among humans with respiratory problems. Dogs are fairly insensitive possibly because long turbinate nasal passage effectively removes any pollutants. For example, 8 dogs exposed to smog plus SO/sub x/ air removed 100% SO/sub 2/, 90% NO/sub 2/, 73% NO, but 0% CO and hydrocarbon during short exposure; also reasonable concentrations of ozone were removed.

• OSTI ID: 6227213
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 19; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
DOGS
EXCRETION
EXHAUST GASES
GASEOUS WASTES
HYDROCARBONS
LUNG CLEARANCE
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR OXIDES
VERTEBRATES
WASTES