Long-term exposure to auto exhaust and other pollutant mixtures

Journal Article · Tue Jan 01 04:00:00 EST 1974 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1974.10666541· OSTI ID:6185829

Lewis, T R; Moorman, W J; Yang, Y; Stara, J F

This is an extension of a preliminary study with beagles exposed to combinations of irradiated and nonirradiated auto exhaust, SO/sub x/ and NO/sub x/. There were no effects after 36 months. After 61 months, 1.21 mg/m/sup 3/ NO/sub 2/ plus 0.31 mg/m/sup 3/ NO reduced pulmonary diffusing capacity but not perfusion and ventilation suggesting alteration of the alveolar capillary membrane. There was no change in tidal flow expiratory resistance although this is less sensitive than peak flow. Raw exhaust plus SO/sub x/ increased the ratio of residual volume to total lung capacity indicating relative hyperinflation not associated with obstructive defects. Exhaust increased pulmonary capillary blood volume suggesting compensation for CO-induced hypoxia. Irradiated exhaust, alone or with SO/sub x/, increased expiratory resistance. Irradiated exhaust impaired ventilatory distribution. Lung volume, compliance, and maximum breathing capacity were not changed by any treatment.

• OSTI ID: 6185829
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 29; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ANOXIA
AUTOMOBILES
BEAGLES
BIOLOGICAL EFFECTS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CHALCOGENIDES
CHRONIC INTAKE
DOGS
DYNAMIC FUNCTION STUDIES
EXHAUST GASES
GASEOUS WASTES
INTAKE
LUNGS
MAMMALS
NITRIC OXIDE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR OXIDES
TOXICITY
VEHICLES
VERTEBRATES
WASTES