A regulatory role for the memory B cell as suppressor-inducer of feedback control
A regulatory role is proposed for the antigen-responsive B cell, as suppressor-inducer of feedback control during the secondary response in vivo. In a double adoptive transfer of memory cells primed to a thymus-dependent antigen from one irradiated host to another, antigen-specific suppressors are generated after a critical time in the primary recipient, able to entirely ablate a secondary anti-hapten response. Positive cell selection in the fluorescence-activated cell sorter confirmed that suppression was mediated by an Lyt-2+ T cell; however, positively selected B cells were also inhibitory and able to induce suppressors in a carrier-specific manner: Bhapten induced suppressors in a carrier-primed population, and Bcarrier induced suppressors in a hapten-carrier population. At the peak of the antibody response in the primary host, memory B cells and their progeny were unable to differentiate further to plasma cells due to their intrinsic suppressor-inducer activity, but this autoregulatory circuit could be severed by adoptive transfer to carrier-primed, X-irradiated recipients.
- Research Organization:
- Division of Immunology, National Institute for Medical Research, London, England
- OSTI ID:
- 6221785
- Journal Information:
- J. Exp. Med.; (United States), Vol. 157:2
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNE REACTIONS
FEEDBACK
LYMPHOCYTES
BIOLOGICAL FUNCTIONS
ANTIGENS
BIOLOGICAL PATHWAYS
HAPTOGLOBINS
IMMUNITY
IN VIVO
MICE
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FUNCTIONS
GLOBULINS
GLOBULINS-ALPHA
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MATERIALS
MUCOPROTEINS
ORGANIC COMPOUNDS
POLYSACCHARIDES
PROTEINS
RADIATIONS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
551000* - Physiological Systems
560152 - Radiation Effects on Animals- Animals