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In vivo persistence of sister chromatid exchanges (SCE) induced by gamma rays in mouse bone marrow cells

Journal Article · · Environ. Mutagen.; (United States)
The sister chromatid exchange (SCE) frequencies induced in bone marrow cells by in vivo irradiation with gamma rays before or after bromodeoxyuridine (BrdUrd) incorporation were compared. The frequency of SCE at different postirradiation times was also measured in bone marrow cells in vivo, irradiated before BrdUrd incorporation. Increased sensitivity to SCE induction by radiation was found in cells after BrdUrd incorporation for one cycle when compared with cells irradiated before BrdUrd incorporation. The increased SCE frequency persisted for at least 72 hr after the initial irradiation, implying that the gamma ray-induced lesion(s) capable of eliciting an SCE are persistent and cannot be easily repaired.
Research Organization:
Instituto Nacional de Investigaciones Nucleares, Mexico City, Mexico
OSTI ID:
6221340
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:4; ISSN ENMUD
Country of Publication:
United States
Language:
English

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