Chromosomal localization of the gene for human B-cell antigen CD40

Journal Article · Sat May 01 04:00:00 EDT 1993 · Somatic Cell and Molecular Genetics; (United States)

DOI:https://doi.org/10.1007/BF01233077· OSTI ID:6220722

Ramesh, N; Geha, R ^[1]; Ramesh, V; Gusella, J F ^[2]

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1. Harvard Medical School, Boston, MA (United States)
2. Massachusetts General Hospital, Boston (United States)

CD40 is a surface glycoprotein expressed on all human B lymphocytes and plays an important role in B-cell development, growth, and differentiation. Anti-CD40 monoclonal antibodies cause isotype switching in B cells treated with IL-4. CD40 is a member of a family of proteins that include low-affinity nerve growth factor receptor, TNF receptor, and the antigen Fas. The ligand for CD40 had been recently identified and had been assigned to the X chromosome. Using a panel of human-rodent somatic cell hybrids, the authors now show that CD40 maps to human chromosome 20.

• OSTI ID: 6220722
• Journal Information: Somatic Cell and Molecular Genetics; (United States), Journal Name: Somatic Cell and Molecular Genetics; (United States) Vol. 19:3; ISSN 0740-7750; ISSN SCMGDN
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANTIBODIES
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
GENES
GLYCOPROTEINS
GROWTH FACTORS
HUMAN CHROMOSOMES
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
MEMBRANE PROTEINS
MITOGENS
MONOCLONAL ANTIBODIES
NERVE TISSUE
ORGANIC COMPOUNDS
PROTEINS
RECEPTORS
SOMATIC CELLS
TISSUES