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Ontogeny of 6-keto-PGF/sub 1. cap alpha. / synthesis in rabbit aorta and the effect of premature weaning

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6220628
; ;
A systematic study of the ontogeny of aortic 6-ketoprostaglandin F/sub 1..cap alpha../ synthesis from birth to adult life and the effect of premature weaning on this process was investigated in rabbits. Prostacyclin (PGI/sub 2/) synthesis by both endogenous and exogenous arachidonic acid and its relation to aortic arachidonic acid content was determined. It was found that 1) PGI/sub 2/ synthesis from endogenous arachidonic acid increased with age, whereas 2) PGI/sub 2/ synthesis from exogenous arachidonic acid decreased. This correlated with a decrease in the incorporation of (/sup 14/C)arachidonic acid into phospholipids with age. Aortic arachidonic acid concentration did not change from birth until 3 wk of life but increased markedly by 5 wk of age. Premature weaning caused a decrease in the synthesis of aortic PGI/sub 2/ and in aortic arachidonic acid concentration initially, but the changes did not persist in later life. These studies suggest that the utilization of exogenous arachidonic acid by aorta decreases after birth perhaps due to maturity of the enzyme systems that synthesize and utilize endogenous substrates.
Research Organization:
Univ. of Cincinnati Medical Center, OH
OSTI ID:
6220628
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:1; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ANIMALS
AORTA
ARACHIDONIC ACID
ARTERIES
BIOSYNTHESIS
BLOOD VESSELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
ENZYME ACTIVITY
ESTERS
LABELLED COMPOUNDS
LIPIDS
MAMMALS
MONOCARBOXYLIC ACIDS
NEONATES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PROSTAGLANDINS
RABBITS
RADIOCHROMATOGRAPHY
SEPARATION PROCESSES
SYNTHESIS
THIN-LAYER CHROMATOGRAPHY
VERTEBRATES