Reparative capacity of animal lungs after exposure to various single and multiple doses of nitrite

Journal Article · Sat Dec 31 23:00:00 EST 1960 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6219503

Kleinerman, J; Wright, G W

Groups of animals were given two-hr acute exposure to high (200 ppM for rabbits, 150 ppM for rats), moderate (100 ppM for rabbits, 75 to 80 ppM for rats and guinea pigs) or low (25 ppM for rabbits, 15 to 20 ppM for rats and guinea pigs) doses of NO/sub 2/. The high dose killed all rats and 33% of the rabbits within 24 hr (edema). All survived the moderate dose with some edema, inflammatory exudate, and epithelial degeneration and regeneration after 24 hr, and progressive repair including macrophage infiltration, until almost complete repair by 2 weeks. There was some repair in low-dose animals but proportionally less initial damage. Multiple (2 hr/day for 5 days) low-dose exposures resulted in less severe inflammation and repair within about 7 days. Respiratory bronchioles were most severely affected.

• OSTI ID: 6219503
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 83; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
DISEASES
EDEMA
EPITHELIUM
GUINEA PIGS
LUNGS
MACROPHAGES
MAMMALS
MORTALITY
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
RABBITS
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SYMPTOMS
TISSUES
VERTEBRATES