Collagen accumulation in irradiated rat lung: modification by D-penicillamine

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.146.2.6849102· OSTI ID:6219327

Ward, W F; Shih-Hoellwarth, A; Tuttle, R D

The collagen antagonist D-penicillamine (10 mg/day, p.o.) significantly ameliorated radiation-induced hydroxyproline (HP) accumulation in the lungs of rats killed 3, 6, 9, or 12 months after a single exposure of 25 Gy of /sup 60/Co gamma rays to the right hemithorax. The beneficial effect of penicillamine was observed when HP values were expressed on the basis of wet weight, dry weight, or per whole lung and was not accompanied by significant changes in the size of the soluble (0.5 M citrate, pH 3.6) collagen fraction. This drug regimen had no effect on HP concentration in the shielded left lung and was apparently free of deleterious side effects.

• Research Organization: Department of Radiology, Northwestern University Medical School, Chicago, IL
• OSTI ID: 6219327
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 146:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COBALT 60
COBALT ISOTOPES
COLLAGEN
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NORTH AMERICA
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PROTEINS
QUANTITY RATIO
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
SIDE EFFECTS
THIOLS
USA
VERTEBRATES
YEARS LIVING RADIOISOTOPES