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Collagen accumulation in irradiated rat lung: modification by D-penicillamine

Journal Article · · Radiology; (United States)
; ;
The collagen antagonist D-penicillamine (10 mg/day, p.o.) significantly ameliorated radiation-induced hydroxproline (HP) accumulation in the lungs of rats killed 3, 6, 9, or 12 months after a single exposure of 25 Gy of /sup 60/Co gamma rays to the right hemithorax. The beneficial effect of penicillamine was observed when HP values were expressed on the basis of wet weight, dry weight, or per whole lung and was not accompanied by significant changes in the size of the soluable (0.5 M citrate, pH 3.6) collagen fraction. This drug regimen had no effect on HP concentration in the shielded left lung and was apparently free of deleterious side effects.
Research Organization:
Northwestern Univ. Medical School, Chicago, IL
OSTI ID:
5815832
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 146:2; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COBALT 60
COBALT ISOTOPES
COLLAGEN
DATA
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES