Inhalation of sulfuric acid mist by human subjects

Journal Article · Tue Jan 01 04:00:00 EST 1952 · Arch. Ind. Hyg. Occup. Med.; (United States)

OSTI ID:6219249

Amdur, M O; Silverman, L; Drinker, P

Retention of inhaled mist (as measured by inhalation--exhalation determinations of concentration by electrostatic precipitation or filter paper) averaged 77% (range 50 to 87%) for exposures of 0.4 to 1 mg/m/sup 3/. Mist particle size average was 1 ..mu..m, which could reach alveoli. Threshold of detection was 1 to 3 mg/m/sup 3/. Average respiration rate of 15 volunteers breathing 0.35, 0.4, or 0.5 mg/m/sup 3/ via mask increased sharply to a plateau of about 35% above control within 5 min and dropped to within 13% of control within 3 min after 15-min exposure. Maximum inspiration and expiration flow rates fell to about 20% below control and returned to near normal after termination of exposure. Tidal volume dropped from about 900 ml to 650 ml within 3 to 4 min, and returned to normal during recovery in 4 min (after initial increase at start of recovery). Rapid, shallow breathing may be a protective reflex (less retention). Higher concentrations of 5 mg/m/sup 3/ could be detected, and response was influenced by this. There was varied response but mainly a decrease in minute volume.

• OSTI ID: 6219249
• Journal Information: Arch. Ind. Hyg. Occup. Med.; (United States), Journal Name: Arch. Ind. Hyg. Occup. Med.; (United States) Vol. 6; ISSN AIHOA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
COLLOIDS
DEPOSITION
DISPERSIONS
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
MAMMALS
MAN
PARTICLE SIZE
PARTICLES
PRIMATES
RESPIRATION
RETENTION
SIZE
SOLS
SULFURIC ACID
VERTEBRATES