Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Pediatr. Pulmonol.; (United States)

DOI:https://doi.org/10.1002/ppul.1950050202· OSTI ID:6213281

Bittera, I; Gyurkovits, K; Falkay, G; Eck, E; Koltai, M

The beta-adrenergic receptor binding sites on peripheral lymphocytes in children with bronchial asthma (n = 16) and seasonal allergic rhinitis (n = 8) were examined in comparison with normal controls (n = 18) by means of /sup 124/I-cyanopindolol. The number of beta-adrenergic receptors was significantly lower in the asthmatic group (858 +/- 460/lymphocyte) than in the controls (1564 +/- 983/lymphocyte). The value (1891 +/- 1502/lymphocyte in children with allergic rhinitis was slightly higher than that in healthy controls. Of the 24 patients suffering from allergic diseases of the lower or upper airways, the bronchial histamine provocation test was performed in 21; 16 gave positive results, while 5 were negative. No difference in beta-adrenergic receptor count was found between the histamine-positive and negative patients. Neither was there any correlation between the number of beta-adrenergic receptors and the high (16/24) and low (8/24) serum IgE concentrations found in allergic patients. The significant decrease in beta-adrenergic receptor count in asthmatic children lends support to Szentivanyi's concept. Further qualitative and quantitative analysis of lymphocyte beta-adrenergic receptors may provide an individual approach to the treatment of bronchial asthma with beta-sympathomimetic drugs.

• Research Organization: Albert Szent-Gyoergyi Univ. Medical School, Szeged (Hungary)
• OSTI ID: 6213281
• Journal Information: Pediatr. Pulmonol.; (United States), Journal Name: Pediatr. Pulmonol.; (United States) Vol. 5:2; ISSN PEPUE
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
ANIMAL CELLS
ASTHMA
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHILDREN
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 124
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEMBRANE PROTEINS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
PATIENTS
PROTEINS
RADIOISOTOPES
RECEPTORS
RESPIRATORY SYSTEM DISEASES
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES