House-dust mite allergen and ozone exposure decreases histamine H3 receptors in the brainstem respiratory nuclei

Journal Article · Wed Sep 15 00:00:00 EDT 2010 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2010.06.014· OSTI ID:21460209

Sekizawa, Shin-ichi ^[1]; Bechtold, Andrea G; Tham, Rick C ^[1]; Kott, Kayleen S ^[1]; Hyde, Dallas M ^[2]; Joad, Jesse P ^[3]; Bonham, Ann C ^[1]

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1. Department of Pharmacology, School of Medicine, University of California Davis, GBSF Rm. 3617, 451 Health Sciences Drive, Davis, CA 95616-0635 (United States)
2. School of Medicine, California National Primate Research Center, University of California Davis, Davis, CA 95616-0635 (United States)
3. Department of Pediatrics, School of Medicine, University of California Davis, Davis, CA 95616-0635 (United States)

Allergic airway diseases in children are a common and a growing health problem. Changes in the central nervous system (CNS) have been implicated in contributing to some of the symptoms. We hypothesized that airway allergic diseases are associated with altered histamine H3 receptor expression in the nucleus tractus solitarius (NTS) and caudal spinal trigeminal nucleus, where lung/airway and nasal sensory afferents terminate, respectively. Immunohistochemistry for histamine H3 receptors was performed on brainstem sections containing the NTS and the caudal spinal trigeminal nucleus from 6- and 12-month-old rhesus monkeys who had been exposed for 5 months to house dust mite allergen (HDMA) + O{sub 3} or to filtered air (FA). While histamine H3 receptors were found exclusively in astrocytes in the caudal spinal trigeminal nucleus, they were localized to both neuronal terminals and processes in the NTS. HDMA + O{sub 3} exposure significantly decreased histamine H3 receptor immunoreactivity in the NTS at 6 months and in the caudal spinal trigeminal nucleus at 12 months of age. In conclusion, exposing young primates to HDMA + O{sub 3} changed histamine H3 receptor expression in CNS pathways involving lung and nasal afferent nerves in an age-related manner. Histamine H3 receptors may be a therapeutic target for allergic asthma and rhinitis in children.

• OSTI ID: 21460209
• Journal Information: Toxicology and Applied Pharmacology, Vol. 247, Issue 3; Other Information: DOI: 10.1016/j.taap.2010.06.014; PII: S0041-008X(10)00217-6; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
AIR
AIR POLLUTION
ASTHMA
CENTRAL NERVOUS SYSTEM
DUSTS
HISTAMINE
HOUSES
LUNGS
NOSE
OZONE
RECEPTORS
AMINES
AZOLES
BODY
BUILDINGS
DISEASES
FACE
FLUIDS
GASES
HEAD
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POLLUTION
PROTEINS
RESIDENTIAL BUILDINGS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES