Blood lead and coronary heart disease risk among elderly men in Zutphen, the Netherlands

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.887843· OSTI ID:6211151

Kromhout, D

Information about blood lead and other coronary heart disease risk factors was collected in 1977 among 152 men aged 57 to 76 years in the town of Zutphen, the Netherlands. Blood lead was determined by atomic absorption spectrometry. The blood lead distribution was skewed to the right. The median blood lead concentration was 167 ..mu..g/L, and the mean was 183 ..mu..g/L. Blood lead levels above 300 ..mu..g/L were present among 8.6% and levels above 400 ..mu..g/L among 1.3% of the Zutphen men. Blood lead was of borderline significance to cigarette smoking. Above both univariate and multivariate analyses, a significant association was found between blood lead and blood pressure. This relation was stronger for systolic than for diastolic blood pressure. Of the 141 elderly men free of coronary heart disease in 1977, 26 developed coronary heart disease between 1977 and 1985. Blood lead was not associated with coronary heart disease incidence in both univariate and multivariate analyses.

• Research Organization: Univ. of Leiden (Netherlands)
• OSTI ID: 6211151
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 78; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
AEROSOLS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
EUROPE
LEAD COMPOUNDS
NETHERLANDS
RESIDUES
RISK ASSESSMENT
SMOKES
SOLS
SPECTROSCOPY
TOBACCO SMOKES
WESTERN EUROPE