Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Physiol. Chem. Phys. Med. NMR; (United States)

OSTI ID:6210431

Jauchem, J R; Frei, M R; Heinmets, F

Anesthetized rats were exposed to 5.6-GHz continuous wave radiofrequency radiation at an average power density of 60 mW/cm2 (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5 degrees C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5 degrees C and continued until lethal temperatures resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermo-regulatory efficiency at colonic temperatures below 39.5 degrees C, the drug caused increased susceptibility to terminal radiofrequency radiation exposure. The present results, when compared to previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal responses to RFR during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.

• Research Organization: Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA)
• OSTI ID: 6210431
• Journal Information: Physiol. Chem. Phys. Med. NMR; (United States), Journal Name: Physiol. Chem. Phys. Med. NMR; (United States) Vol. 20:2; ISSN PCPNE
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BODY TEMPERATURE
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORPROMAZINE
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY
HEAT
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIATIONS
RADIOWAVE RADIATION
RATS
RODENTS
SURVIVAL TIME
TRANQUILIZERS
VERTEBRATES