In vivo cross-match by chromium-51 urinary excretion from labeled erythrocytes: A case of anti-Gerbich

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6210007

Mochizuki, T; Tauxe, W N; Ramsey, G ^[1]

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1. Univ. of Pittsburgh School of Medicine, PA (USA)

We studied a patient with an alloantibody to the high-frequency red blood cell (RBC) antigen Gerbich. A nationwide search for rare Gerbich-negative blood (less than 1:45,000 donors) located only seven units, and our supply was quickly exhausted. By using an in vivo cross-matching method, we demonstrated that this anti-Gerbich did not cause RBC destruction. Regular Gerbich-positive transfusions could then proceed without hemolysis. This cross-match test was based on the determination of the urinary excretion rates of injected radioactive chromium-labeled donor erythrocytes by which it was possible to determine compatibility only 24 hr after the test was begun. The procedure provides an easy and accurate means for in vivo cross-matching of conventionally incompatible donor blood.

• OSTI ID: 6210007
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:12; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD GROUPS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
EXCRETION
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
NUCLEI
PATIENTS
RADIOISOTOPES
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS