Sources of error in the determination of trichloroethylene in blood

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701820· OSTI ID:6207763

Gorski, T; Goehl, T J; Jameson, C W; Collins, B J ^[1]

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1. National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)

One of the more common methods in determining volatile chemicals in biological samples involves an extraction procedure followed by a chromatographic quantitation step. These analytical methods are generally validated using conventional techniques with some attempts to minimize analyte losses during sample handling. After a successful validation, the analyst will feel confident that the procedure employed would provide an accurate determination of the analyte in the sample. However, it is difficult or sometimes impossible to identify precisely the losses that occur during sample handling. In this paper problems associated with the accurate determination of the volatile analyte, trichloroethylene, (TCE) are addressed. Gas chromatography was performed with a Perkin-Elmer Sigma 2000 chromatograph equipped with a 63Ni detector. Experiments to determine recovery of TCE were performed on both water and blood samples.

• OSTI ID: 6207763
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 45:1; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CHEMICAL ANALYSIS
CHLORINATED ALIPHATIC HYDROCARBONS
CHROMATOGRAPHY
ERRORS
GAS CHROMATOGRAPHY
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
SAMPLE PREPARATION
SEPARATION PROCESSES
WATER