Laser-irradiation-induced relaxation of blood vessels in vivo

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Lasers in Surgery and Medicine; (USA)

DOI:https://doi.org/10.1002/lsm.1900100604· OSTI ID:6207326

Gourgouliatos, Z F; Welch, A J; Diller, K R; Aggarwal, S J ^[1]

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1. Univ. of Texas, Austin (USA)

The response of blood vessels to laser irradiation in vivo was studied in the dorsal skin flap glass window chamber model of hamsters. The vasodilatory response of venules was critically dependent on the wavelength of irradiating laser. Relaxation was not produced in arterioles, although it was tried repeatedly. Vessels were irradiated with the 514.5 nm single line argon laser with irradiances from 1 to 10 W/cm{sup 2} on a 1.2 mm-diameter spot. Irradiation of venules with 2.2 W/cm{sup 2} and 4.25 W/cm{sup 2} produced reversible relaxation. Venules relaxed initially and after the interruption of irradiation returned to their original diameter. At higher irradiances (8.5 W/cm{sup 2}) an irreversible relaxation was observed. At irradiances of 10 W/cm{sup 2} and above initial relaxation was accompanied with constriction, focal coaguli, and hemostasis. Irradiation with the argon-pumped dye laser at 595 nm did not produce any significant relaxation.

• OSTI ID: 6207326
• Journal Information: Lasers in Surgery and Medicine; (USA), Journal Name: Lasers in Surgery and Medicine; (USA) Vol. 10:6; ISSN LSMED; ISSN 0196-8092
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DRUGS
DYE LASERS
ELECTROMAGNETIC RADIATION
FEASIBILITY STUDIES
HAMSTERS
LASER RADIATION
LASERS
LIQUID LASERS
MAMMALS
ORGANS
RADIATIONS
RODENTS
SENSITIVITY
SKIN
VASODILATORS
VERTEBRATES