Histologic comparison of the pulsed dye laser and copper vapor laser effects on pig skin

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Lasers in Surgery and Medicine; (USA)

DOI:https://doi.org/10.1002/lsm.1900100607· OSTI ID:5982379

Tan, O T; Stafford, T J; Murray, S; Kurban, A K ^[1]

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1. Boston Univ. Medical Center, MA (USA)

Albino pig skin was exposed to the copper vapor (CVL) and flash-lamp pulsed dye (PDL) lasers at 578 nm with a 3 mm diameter spotsize over a range of fluences until purpura and whitening were first established. The total irradiation time was the parameter that was varied in order for the CVL to reach the desired fluence. The lowest fluence producing each clinical endpoint was designated the threshold fluence: 34 J/cm{sup 2} was required to produce purpura using the CVL compared to 7.5 J/cm{sup 2} with the PDL laser. Histologically, skin exposed to purpura fluences from the CVL revealed the presence of constricted, disrupted papillary dermal blood vessels with trapped RBC's within them which were unlike those exposed to PDL where the irradiated vessels were dilated and packed with masses of intravascular agglutinated RBC's. The whitening threshold fluences for the CVL and PDL lasers were 67 J/cm{sup 2} and 29 J/cm{sup 2}, respectively. Streaming of epidermal cells and dermal collagen denaturation were observed in CVL irradiated skin, compared to occasional dyskeratotic epidermal cells and focal dermal collagen denaturation following PDL exposure. The mechanisms responsible for the clinical and histologic changes produced by the two laser systems are discussed.

• OSTI ID: 5982379
• Journal Information: Lasers in Surgery and Medicine; (USA), Journal Name: Lasers in Surgery and Medicine; (USA) Vol. 10:6; ISSN 0196-8092; ISSN LSMED
• Country of Publication: United States
• Language: English

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560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COLLAGEN
COMPARATIVE EVALUATIONS
DOMESTIC ANIMALS
DYE LASERS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
LASER RADIATION
LASERS
LIQUID LASERS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIATIONS
SCLEROPROTEINS
SKIN
SWINE
VERTEBRATES