Status of human chromosome aberrations as a biological radiation dosimeter in the nuclear industry

Conference · Sun Jan 01 04:00:00 EST 1978

OSTI ID:6203328

Bender, M A

It seems that the determination of peripheral lymphocyte chriomosome aberration levels is now firmly established as a means of biological dosimetry of great value in many phases of the nuclear industry. In the case of large external exposure it can provide valuable quantitative estimates, as well as information on dose distribution and radiation quality. In the case of routine occupational exposures the technique is more qualitative, but is of value particularly in resolving uncertainties as to whether suspected overexposures did in fact occur. Where workers accumulate burdens of internal emitters, aberration analysis provides a valuable, though at present quite qualitative indicator. In spite of the expense of cytogenetic analyses, they are of sufficient value to justify much more widespread application, particularly in high risk situations.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 6203328
• Report Number(s): BNL-25281; CONF-781215-2
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL DOSEMETERS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSEMETERS
DOSIMETRY
ENERGY TRANSFER
EXTERNAL IRRADIATION
INTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
LET
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MEASURING INSTRUMENTS
MUTATIONS
PATIENTS
PERSONNEL
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES