Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with /sup 60/Co or fast neutrons. [/sup 133/Xe and /sup 99m/Tc--Sn--phytate]

Journal Article · Thu Feb 01 00:00:00 EST 1979 · Radiology; (United States)

OSTI ID:6202836

Alderson, P O; Bradley, E W; Mendenhall, K G; Vieras, F; Siegel, B A; Sloan, G E; Rogers, C C

To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion, and aerosol studies at three-, six-, nine-, and twelve-month intervals after hemithorax irradiation with /sup 60/Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 6202836
• Journal Information: Radiology; (United States), Vol. 130:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
FAST NEUTRONS
RBE
LUNGS
DELAYED RADIATION EFFECTS
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
TECHNETIUM 99
XENON 133
BEAGLES
BIOLOGICAL FUNCTIONS
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GAMMA RADIATION
ISOMERIC NUCLEI
LOCAL IRRADIATION
MEV RANGE 10-100
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PHYTIC ACID
RADIOCOLLOIDS
TIN COMPLEXES
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
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COLLOIDS
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DIAGNOSTIC TECHNIQUES
DISPERSIONS
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EXTERNAL IRRADIATION
FERMIONS
HADRONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIPOTROPIC FACTORS
MAMMALS
MEV RANGE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHORIC ACID ESTERS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPE SCANNING
RADIOISOTOPES
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