Second malignant lesions after therapy for Hodgkin's disease

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Mayo Clin., Proc.; (United States)

DOI:https://doi.org/10.1016/S0025-6196(12)60440-6· OSTI ID:6201517

Schomberg, P J; Evans, R G; Banks, P M; White, W L; O'Connell, M J; Earle, J D

Among 169 adult pathologically staged patients with Hodgkin's disease who were treated at the Mayo Clinic between 1974 and 1978, four cases of second malignant lesions were identified. The median duration of follow-up after diagnosis for the entire population was 4.1 years. Of the 169 patients, 73 received irradiation only, 19 received chemotherapy only, and 77 received both chemotherapy and radiation therapy. In all four patients with second malignant lesions, Hodgkin's disease was in apparent remission at the time of diagnosis of the second tumor. These four patients had received either total nodal irradiation or six or more cycles of chemotherapy as initial treatment (and one of them had received both treatment modalities). Thus, intensive therapy might be hypothesized to have played a role in the development of the second malignant tumor. The development of non-Hodgkin's lymphoma within a previously irradiated field after treatment of Hodgkin's disease with radiation therapy only is not know to have been reported previously. Although further studies with longer follow-up should be conducted, this analysis supports a definite risk for development of a second malignant lesion not only after combined-modality treatment or chemotherapy for Hodgkin's disease but also after irradiation only.

• OSTI ID: 6201517
• Journal Information: Mayo Clin., Proc.; (United States), Journal Name: Mayo Clin., Proc.; (United States) Vol. 59:7; ISSN MACPA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMOTHERAPY
DISEASES
HODGKINS DISEASE
LYMPHOMAS
MEDICAL SURVEILLANCE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVEILLANCE
THERAPY
TIME DEPENDENCE