Psoralen-plus-light damage and repair in transforming DNA of Bacillus subtilis
Conference
·
OSTI ID:6196010
The relative contributions of excision and recombination in the repair of damage by 8-methoxypsoralen (8-MOP) plus black light to Bacillus subtilis were studied. The results indicate that the pyrimidine dimer excision system and a recombination pathway are probably both involved in repair of lethal damage to cells exposed in vivo to 8-MOP plus black light, but repair is not very efficient. Transforming DNA exposed in vitro to 8-MOP plus black light was inactivated mainly by crosslinks rather than by monoadducts, and was repaired predominantly by an incision-dependent process. There was very little demonstrable damage-induced recombination in transforming DNA.
- Research Organization:
- Oak Ridge National Lab., TN (USA); Tennessee Univ., Oak Ridge (USA). Graduate School of Biomedical Sciences
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6196010
- Report Number(s):
- CONF-810694-1; ON: DE81024140
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560112* -- Radiation Effects on Biochemicals-- In Microorganisms-- (-1987)
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTICOAGULANTS
BACILLUS
BACILLUS SUBTILIS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COUMARINS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
IN VIVO
IRRADIATION
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
ULTRAVIOLET RADIATION
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTICOAGULANTS
BACILLUS
BACILLUS SUBTILIS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COUMARINS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
IN VIVO
IRRADIATION
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
ULTRAVIOLET RADIATION