Long-term effects of intragastic instillations of BDNPF:BDNPA in male Sprague-Dawley rats and female Swiss-Webster mice

Technical Report · Wed Jul 01 04:00:00 EDT 1981

OSTI ID:6194687

Smith, D M; Drake, G A; London, J E

Young male Sprague-Dawley rats were given a single dose of 1.3 g/kg body weight (BW) bis-dinitro-propyl-formal:bisdinitro-propyl-acetal (BDNPF:BDNPA) intragastrically (IG) and young female Swiss-Webster mice were given BDNPF:BDNPA either as a single dose (800 mg/kg/Bw) IG or a dose (500 mg/kg/BW) IG on each of 5 consecutive days. All animals were then maintained for the durations of their life spans and autopsied at death. The incidence of testicular Leydig cell tumors and subcutaneous fibrosarcomas in rats receiving the material was significantly elevated compared to controls, though treated animals' life spans were not significantly different from those of control animals. No significant effects were seen in any of the mice receiving either a single dose or multiple doses of BDNPF:BDNPA compared to control animals. We suggest that another species of male Laboratory animals be treated with BDNPF:BDNPA to see if these findings can be replicated.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6194687
• Report Number(s): LA-8924-MS; ON: DE81028597
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID ESTERS
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
CARBOXYLIC ACID ESTERS
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DISEASES
ESTERS
FEMALES
FIBROSARCOMAS
GENETIC VARIABILITY
GONADS
JUVENILES
LIFE SPAN
MALE GENITALS
MALES
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SARCOMAS
SEX DEPENDENCE
SKIN
TESTES
VERTEBRATES