Long-term effects of intragastric instillations of silastic 386 foam elastomer

Technical Report · Tue Dec 01 04:00:00 EST 1981

DOI:https://doi.org/10.2172/5206030· OSTI ID:5206030

Smith, D. M.; Drake, G. A.; London, J. E.

Young male Sprague-Dawley rats (87 days old) were given a single dose (5 g/kg body weight (BW)) of Silastic 386 foam elastomer intragastrically (IG), and young female Swiss-Webster mice (83 days old) were given a single dose (5 g/kg BW) IG, or a dose (1 g/kg BW) IG on each of 5 consecutive days, of Silastic 386 foam elastomer. All animals were then maintained for the rest of their lives and autopsied at death. No significant effects resulting from the oral administration of this of this material were seen in any of the rats or mice.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 5206030
• Report Number(s): LA-9085-MS; ON: DE82010019
• Country of Publication: United States
• Language: English

Related Subjects

550901 -- Pathology-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTOPSY
BIOLOGICAL EFFECTS
COLLOIDS
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
ELASTOMERS
EPIDEMIOLOGY
FOAMS
INGESTION
INTAKE
LIFE SPAN
LYMPHOMAS
MAMMALS
NEOPLASMS
POLYMERS
RATS
RODENTS
TOXICITY
VERTEBRATES