Effects of methanol vapor on human neurobehavioral measures. Research report, Jul 88-Oct 90
Methanol may become an important alternative fuel for vehicles in the near future. The objective of the preliminary study was to determine if inhalation exposure to methanol, near the maximum concentration allowed for an eight-hour average exposure in the workplace (200 ppm), would have adverse effects on human neurobehavioral functions. Twelve healthy young men were exposed twice to filtered air and twice to 192 ppm methanol vapors for 75 minutes on different days under double-blind conditions. Twenty-two neurobehavioral and neurophysiological tests were administered before, during, and after exposure to measure visual, behavioral, reasoning, and hearing functions. Exposure to methanol produced significant increases in blood and urine methanol concentration at the end of the exposure period. As expected, no changes in plasma formate were observed. Methanol exposure had no effect on the subjects' performance on most of the tests. However, some methanol-exposed subjects reported more fatigue and lack of concentration. Performance was also slightly impaired on the Sternberg memory task. There were also changes in the latency of the P200 component of the visual- and auditory-event related potential. These effects were small and did not exceed the range of results measured in filtered air-exposed subjects.
- Research Organization:
- Midwest Research Inst., Kansas City, MO (United States). Life Sciences Dept.
- OSTI ID:
- 6194686
- Report Number(s):
- PB-91-243253/XAB
- Resource Relation:
- Other Information: Sponsored by Health Effects Inst., Cambridge, MA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
METHANOL
TOXICITY
NERVOUS SYSTEM
SENSITIVITY
BEHAVIOR
BODY FLUIDS
INHALATION
MAN
MAXIMUM PERMISSIBLE EXPOSURE
METABOLISM
PHYSIOLOGY
VAPORS
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
FLUIDS
GASES
HYDROXY COMPOUNDS
INTAKE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PRIMATES
SAFETY STANDARDS
STANDARDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology