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Risk of breast cancer following low-dose radiation exposure

Conference · · Radiology; (United States)
OSTI ID:6187222
; ; ; ;

Risk of breast cancer following radiation exposure was studied, based on surveys of tuberculosis patients who had multiple fluoroscopic examinations of the chest, mastitis patients given radiotherapy, and atomic bomb survivors. Analysis suggests that the risk is greatest for persons exposed as adolescents, although exposure at all ages carries some risk. The dose-response relationship was consistent with linearity in all studies. Direct evidence of radiation risk at doses under 0.5 Gy (50 rad) is apparent among A-bomb survivors. Fractionation does not appear to diminish risk, nor does time since exposure (even after 45 years of observation). The interval between exposure and the clinical appearance of radiogenic breast cancer may be mediated by hormonal or other age-related factors but is unrelated to dose. Age-specific absolute risk estimtes for all studies are remarkably similar. The best estimate of risk among American women exposed after age 20 is 6.6 excess cancers/10/sup 4/ WY-Gy (10/sup 6/ WY-rad).

OSTI ID:
6187222
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 131:3; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
AGE DEPENDENCE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
CARCINOGENESIS
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
FEMALES
FLUOROSCOPY
GLANDS
HAZARDS
HEALTH HAZARDS
IONIZING RADIATIONS
IRRADIATION
LATENCY PERIOD
LOW DOSE IRRADIATION
MAMMALS
MAMMARY GLANDS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOGENESIS
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
THERAPY
VERTEBRATES
WOMEN