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Genetic and physiological factors affecting repair and mutagenesis in yeast

Technical Report ·
DOI:https://doi.org/10.2172/6184830· OSTI ID:6184830
Current views of DNA repair and mutagenesis in the yeast Saccharomyces cerevisiae are discussed in the light of recent data, and with emphasis on the isolation and characterization of genetically well-defined mutations that affect DNA metabolism in general (including replication and recombination). Various pathways of repair are described particularly in relation to their involvement in mutagenic mechanisms. In addition to genetic control, certain physiological factors such as cell age, DNA replication, and the regulatory state of the mating-type locus, are shown to also play a role in repair and mutagenesis.
Research Organization:
Oak Ridge National Lab., TN (USA)
Sponsoring Organization:
Not Available; USDOE
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6184830
Report Number(s):
CONF-790676-3
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550400 -- Genetics
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGICAL VARIABILITY
CARBONIC ACID DERIVATIVES
COMPARATIVE EVALUATIONS
DATA
DATA COMPILATION
DATA FORMS
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EMS
ESTERS
FUNGI
GENE RECOMBINATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETIC VARIABILITY
GUANIDINES
HYDRAZINE
HYDROGEN COMPOUNDS
INFORMATION
INORGANIC ACIDS
IRRADIATION
ISOLATED VALUES
METHYL METHANESULFONATE
MICROORGANISMS
MUTAGENESIS
MUTAGENS
MUTATIONS
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
NITROUS ACID
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
YEASTS