Reduction and mutagenic activation of nitroaromatic compounds by a Mycobacterium sp.
Journal Article
·
· Applied and Environmental Microbiology
OSTI ID:61824
- National Center for Toxicological Research, Jefferson, AR (United States)
Nitropolycyclic aromatic hydrocarbons (nitro-PAHs) constitute a widely distributed class of environmental pollutants. Nitro-PAHs are metabolized by various oxidative and reductive enzymes from bacterial and fungal and mammalian systems. Reduction of nitro-PAHs produces arylhydroxylamines. These metabolites bind to DNA and induce mutagenesis. DNA damaging products can be detected only only by the Ames test but also by the umu test. In this study the researchers found that Mycobacterium sp. strain Pyr-1 produced nitroreductase activity that activated nitro-PAHs to DNA-damaging products, which were detected by the reversion and umu tests. 36 refs., 2 figs., 3 tabs.
- OSTI ID:
- 61824
- Journal Information:
- Applied and Environmental Microbiology, Journal Name: Applied and Environmental Microbiology Journal Issue: 12 Vol. 60; ISSN AEMIDF; ISSN 0099-2240
- Country of Publication:
- United States
- Language:
- English
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