Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

Journal Article · Thu Apr 01 04:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6180231

Smith, S A; Ponder, M; Pye, C; Ponder, B A.J. ^[1]; Easton, D F; Ford, D; Peto, J; Anderson, K; Averill, D; Stratton, M ^[2]

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1. Univ. of Cambridge (United Kingdom)
2. Inst. of Cancer Research, Surrey (United Kingdom)

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at [theta] = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250. 9 refs., 2 figs., 4 tabs.

• OSTI ID: 6180231
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:4; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL VARIABILITY
BODY
CHROMOSOMES
DISEASES
DNA HYBRIDIZATION
FEMALE GENITALS
GENE RECOMBINATION
GENETIC MAPPING
GENETIC VARIABILITY
GLANDS
GONADS
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
HYBRIDIZATION
MAMMARY GLANDS
MAPPING
NEOPLASMS
ORGANS
OVARIES
RFLPS