Linkage of a major breast cancer gene to chromosome 17q12-21: Results from 15 Edinburgh families

Journal Article · Thu Apr 01 04:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6180275

Cohen, B B; Porter, D E; Wallace, M R; Carothers, A; Steel, C M ^[1]

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1. Western General Hospital, Edinburgh (United Kingdom)

DNA from members of 15 pedigrees each containing between three and eight cases of breast cancer have been collected from southeastern Scotland. Polymorphic markers on chromosome 17q were screened to locate a putative breast cancer gene by using DNA from relevant individuals within these families. Pairwise LOD scores were calculated for markers D17S74, NM23, D17S588, and D17S579. The maximal summated LOD for the 15 families was 5.44 at [theta] = .034, when D17S588 (42D6) was used. In these breast cancer families, a subset which did not give evidence for linkage to this region could be identified. Linkage to a breast cancer gene on 17q12-21 cannot definitely be confirmed or refuted in any single family in this series. Taken together, however, these data offer strong support for a major gene at this locus. 9 refs., 2 figs., 2 tabs.

• OSTI ID: 6180275
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:4; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BODY
CHROMOSOMES
DEVELOPED COUNTRIES
DISEASES
DNA HYBRIDIZATION
EUROPE
GENETIC MAPPING
GLANDS
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
HYBRIDIZATION
MAMMARY GLANDS
MAPPING
NEOPLASMS
ORGANS
RFLPS
UNITED KINGDOM
WESTERN EUROPE